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. 1975;151(6):321-32.

Dermatopharmacology of salicylic acid. II. Epidermal antihyperplastic effect of salicylic acid in animals

E G Weirich, J K Longauer, A H Kirkwood
  • PMID: 1228007

Dermatopharmacology of salicylic acid. II. Epidermal antihyperplastic effect of salicylic acid in animals

E G Weirich et al. Dermatologica. 1975.

Abstract

The influence of salicylic acid on pathological epithelial proliferation has been evaluated by means of the peidermal hyperplasia inhibition test in the guinea pig. 3% w/w salicylic acid dissolved in ethanol reduced surface epithelial hyperplasia by 15%, i.e. exhibited activity comparable to that of hydrocortisone 0.1% w/w. 1% w/w salicylic acid dissolved in a dimethylacetamide-acetone-ethanol mixture exerted an even greater degree of antihyperplastic activity on the surface epithelium (-18%) and also a marked inhibitory effect on deep epithelial proliferation (-10%).

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