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. 2002 Oct 2;124(39):11684-8.
doi: 10.1021/ja027433h.

The copper-catalyzed N-arylation of indoles

Jon C Antilla  1 , Artis Klapars, Stephen L Buchwald
Affiliations

The copper-catalyzed N-arylation of indoles

Jon C Antilla et al. J Am Chem Soc. .

Abstract

A general method for the N-arylation of indoles using catalysts derived from CuI and trans-1,2-cyclohexanediamine (1a), trans-N,N'-dimethyl-1,2-cyclohexanediamine (2a), or N,N'-dimethyl-ethylenediamine (3) is reported. N-Arylindoles can be produced in high yield from the coupling of an aryl iodide or aryl bromide with a variety of indoles.

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