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Comment
. 2002 Oct;130(1):1-3.
doi: 10.1046/j.1365-2249.2002.01979.x.

Leaked protein and interstitial damage in the kidney: is complement the missing link?

N S Sheerin  1 , S H Sacks
Affiliations
Comment

Leaked protein and interstitial damage in the kidney: is complement the missing link?

N S Sheerin et al. Clin Exp Immunol. 2002 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic representation of the possible roles of complement in the generation of tubulointerstitial inflammation and fibrosis. Complement components derived from either the glomerular infiltrate or local synthesis by resident cells are activated on the luminal border of the PTECs with the generation of C5B-9 and C5a. These products activate PTECs leading to synthesis of new matrix, secretion of fibrogenic and proinflammatory cytokines and cell apoptosis. Additionally, C5a may have a direct chemoattractant effect.
See this image and copyright information in PMC

Comment on

References

    1. Morita Y, Ikeguchi H, Nakamura J, Hotta N, Yuzawa Y, Matsuo S. Complement activation products in the urine from proteinuric patients. J Am Soc Nephrol. 2000;11:700–7. - PubMed
    1. Mosolitis S, Magyarlaki T, Nagy J. Membrane attack complex and membrane cofactor protein are related to tubulointerstitial inflammation in various human glomerulopathies. Nephron. 1997;75:179–85. - PubMed
    1. Nath KA, Hostetter MK, Hostetter TH. Pathophysiology of chronic tubulo-interstitial disease in rats. J Clin Invest. 1985;76:667–75. - PMC - PubMed
    1. David S, Biancone L, Caserta C, Bussolati B, Cambi V, Camussi G. Alternative pathway complement activation induces proinflammatory activity in human proximal tubular epithelial cells. Nephrol Dial Transplant. 1997;12:51–6. - PubMed
    1. Lovett DH, Haensch GM, Goppelt M, Resch K, Gemsa D. Activation of glomerular mesangial cells by the terminal membrane attack complex of complement. J Immunol. 1987;138:2473–80. - PubMed

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