Progesterone in large amounts has immunosuppressive effect
- PMID: 12307301
Progesterone in large amounts has immunosuppressive effect
Abstract
PIP: The immunosuppressive effect of large amounts of progesterone was studied. Progesterone was placed inside porous Silastic tubes which were wrapped with antigenic substances (cotton thread or hamster skin) and placed in the flanks of female animals. Control implants contained nothing or other steroids such as estrogen. An inflammatory response consisting of the proliferation of granulomatous tissue and adhesions appeared within a week in the controls whereas the experimental implants elicited almost no inflammatory response. In the hamster control skin-wrapped implants, complete destruction of skin occurred within 8-10 days and all the implants containing progesterone survived for more than 2 weeks and as long as 35 or 40 days. Experiments involved in the ability of progesterone to inhibit the human mixed lymphocyte reaction revealed that at levels comparable to those in the human placenta, progesterone exerted marked suppression and inhibition. It is suggested that this effect is mediated at the level of the T lymphocytes and the activity of progesterone in high concentrations appears similar to that of the glucocorticoid hormones in achieving immunosuppression.
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