Distribution of 67Ga in organs of mice with lymphoid leukaemia

Abstract

Distribution of 67Ga in different organs of A/H mice bearing a lymphatic leukaemia was examined. Mice received 10(6) leukaemia cells intravenously and groups of 6 mice were sacrificed every other day. Twenty-four hours before sacrifice, the mice received intraperitoneal injection of 67Ga. Spleen, lymph nodes, liver, left kidney, lung, left femur, and a sample of blood were taken, to determine their radioactivity. The maximum of 67Ga uptake was on the 7th day after transplantation of the leukaemia, whereas before death it declined to the values observed in control mice without leukaemia. The changes are interpreted in terms of the ability of leukaemia cells and of macrophages to bind 67Ga.