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. 1975;8(1):79-81.
doi: 10.1007/BF00616419.

Acetylation of procaine amide in man. A preliminary communication

E Karlsson, G Aberg, P Collste, L Molin, B Norlander, F Sjöqvist

Acetylation of procaine amide in man. A preliminary communication

E Karlsson et al. Eur J Clin Pharmacol. 1975.

Abstract

The metabolism of procaine amide was studied in 41 cardiac patients who had achieved steady state plasma concentrations of the drug. Acetylated procaine amide accounted for 31 +/- 12% (range 16-63%) of the overall urinary recovery of the drug and is therefore a main metabolite in man. Plasma levels of the metabolite were usually lower but sometimes exceeded those of the parent compound with variations between 1 and 15 mug/ml. The metabolite had a weaker effect than procaine amide on the maximal electrical driving velocity of isolated atrial strips from guinea pig.

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