doi: 10.1007/BF00561564.
General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments
- PMID: 1233210
- DOI: 10.1007/BF00561564
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General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments
Eur J Clin Pharmacol.
.
Abstract
General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readily obtainable using disposition and input functions.
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