doi: 10.1007/BF00614023.
General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate intravenous infusions
- PMID: 1233268
- DOI: 10.1007/BF00614023
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General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate intravenous infusions
Eur J Clin Pharmacol.
.
Abstract
Steady state plasma drug concentrations can be achieved rapidly and safely by a drug input mode consisting of two consecutive constant rate intravenous infusions. A general method for calculating the relative rates of the two infusions is presented. The derivation is independent of the concepts of compartmental distribution and elimination of drugs within the body.
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