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. 1975 Dec 19;9(2-3):235-8.
doi: 10.1007/BF00614023.

General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate intravenous infusions

D P Vaughan, G T Tucker

General theory for rapidly establishing steady state drug concentrations using two consecutive constant rate intravenous infusions

D P Vaughan et al. Eur J Clin Pharmacol. .

Abstract

Steady state plasma drug concentrations can be achieved rapidly and safely by a drug input mode consisting of two consecutive constant rate intravenous infusions. A general method for calculating the relative rates of the two infusions is presented. The derivation is independent of the concepts of compartmental distribution and elimination of drugs within the body.

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References

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