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. 1979 Apr;29(2):274-82.

Termination of second trimester pregnancy with single intra-amniotic and extra-amniotic instillation of prostaglandin F2 alpha and 15-methyl prostaglandin F2 alpha

A Sethi, S F Jalnawalla
  • PMID: 12335893

Termination of second trimester pregnancy with single intra-amniotic and extra-amniotic instillation of prostaglandin F2 alpha and 15-methyl prostaglandin F2 alpha

A Sethi et al. J Obstet Gynaecol India. 1979 Apr.

Abstract

PIP: The use of high doses of prostaglandin F2 Alpha and 15-Methyl prostaglandin F2 Alpha have proved highly successful in the termination of second trimester pregnancy. The present study evaluates experience obtained from using the recommended single dosage schedules and compares the relative effectiveness and safety of intra-amniotic and extra-amniotic routes. The success rates of intra-amniotic administration of PGF2 alpha and 15-methyl PGF2 alpha by transabdominal amniocentesis via polyethylene catheter threaded through an 18 gauge needle were 93.9% and 98% respectively. The number of incomplete abortions were also higher in the extra-amniotic group, being 80.2% with 15-me-F2 alpha as compared with 28.0% with intra-amniotic 15-me-F2 and 23.9% with intra-amniotic F2 alpha. This difference, however, is probably due to the fact that women in the intra-amniotic group had a completely formed placenta. The mean induction time was approximately the same for all groups and occurred within 24 hours. Parity had no significant correlation with the success rate, nor did the period of gestation (between 10 and 20 weeks). The latter factor had no correlation with complete or incomplete abortion, or the abortion induction interval. 18 cases out of the 20 studied failed to abort due to unresponsiveness of the uterus to the drug. The incidence of major side effects such as vomiting and diarrhea were comparable and clinically acceptable.

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