Histamine H1 and H2 receptor activities in guinea-pig isolated arteries
- PMID: 1233819
Item in Clipboard
Histamine H1 and H2 receptor activities in guinea-pig isolated arteries
West Afr J Pharmacol Drug Res.
1975 Dec.
Abstract
The actions of histamine, 2-methylhistamine (2 MeH) and 4-methylhistamine (4 MeH) were studied in isolated muscle preparations from pulmonary artery, aorta and terminal ileum of guinea-pigs. Relative to histamine, 2 MeH had a significantly higher activity in the arteries than in the ileum. In the arteries, 4 MeH inhibited 2 MeH--and histamine-induced contractions. Burimamide blocked the inhibitory effect of 4 MeH and potentiated histamine but not 2 MeH induced contractions in arteries. The results show that the arterial muscles studied contain both H1 and H2 receptors subserving contractile and dilator effects respectively.
Similar articles
-
Histamine receptors in the myenteric plexus-longitudinal muscle of the guinea-pig ileum: H1- and H2-receptor-mediated potentiation of the contractile response to electrical stimulation.J Pharmacol Exp Ther. 1982 Oct;223(1):177-82. J Pharmacol Exp Ther. 1982. PMID: 6126581
-
Interactions between histaminergic and cholinergic pathways of gastric motility regulation.Methods Find Exp Clin Pharmacol. 1996 Jan-Feb;18(1):33-9. Methods Find Exp Clin Pharmacol. 1996. PMID: 8721254
-
Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971.Arzneimittelforschung. 1998 Sep;48(9):881-8. Arzneimittelforschung. 1998. PMID: 9793613
-
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.J Pharmacol Exp Ther. 1992 Feb;260(2):762-7. J Pharmacol Exp Ther. 1992. PMID: 1531360
-
[The mechanism of action of histamine on the myocardium and the smooth vascular muscles].Fortschr Med. 1977 Oct 6;95(37):2251-5. Fortschr Med. 1977. PMID: 199533 German.