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. 1975 Mar:1:23-8.

Influence of metformin on arginine-induced glucagon secretion in human diabetes

J Carpentier, A S Luyckx, P J Lefebvre
  • PMID: 1234063

Influence of metformin on arginine-induced glucagon secretion in human diabetes

J Carpentier et al. Diabete Metab. 1975 Mar.

Abstract

The insulin and glucagon responses to arginine infusion were investigated in patients with maturity-onset diabetes under control conditions and during metformin therapy. Metformin did not significantly affect the insulin nor the glucagon response to arginine. These data support the concept that biguanide do not act directly on the islets of Langerhans.

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