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. 1975 Oct;35(5):443-5.
doi: 10.1136/ard.35.5.443.

Serum copper and caeruloplasmin in ankylosing spondylitis, systemic sclerosis, and morphea

M I Jayson, P Davis, J T Whicher, G Walters

Serum copper and caeruloplasmin in ankylosing spondylitis, systemic sclerosis, and morphea

M I Jayson et al. Ann Rheum Dis. 1975 Oct.

Abstract

Studies of serum copper and caeruloplasmin were performed in patients with ankylosing spondylitis, systemic sclerosis, and morphea. Mean levels of both were raised significantly in ankylosing spondylitis, with the greatest increases in the worst cases. In patients with systemic sclerosis there was a significant increase in the mean level of caeruloplasmin, but not of copper, although both were raised in the 2 patients with the most aggressive disease. No alterations were found in patients with morphea. The values in the patients overlapped considerably with the values in the control subjects. It is thought that the increase in serum copper is probably secondary to the increase in caeruloplasmin which occurs as a nonspecific response to inflammation.

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References

    1. Scand J Rheumatol. 1975;4(1):33-8 - PubMed
    1. Lancet. 1974 Feb 9;1(7850):187-92 - PubMed
    1. Biochim Biophys Acta. 1973 Apr 13;306(1):74-81 - PubMed
    1. J Chronic Dis. 1971 Jan;23(8):527-36 - PubMed
    1. Pharmacol Rev. 1960 Sep;12:355-81 - PubMed