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Comparative Study
. 1975 Feb;2(1):73-9.
doi: 10.1111/j.1365-2125.1975.tb00475.x.

Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding

M J Hayes, M J Langman, A H Short
Comparative Study

Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding

M J Hayes et al. Br J Clin Pharmacol. 1975 Feb.

Abstract

1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.

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