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. 2002 Sep;42(20):2333-7.
doi: 10.1016/s0042-6989(02)00188-8.

Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model

Frank Schuettauf  1 , Kristine Quinto, Rita Naskar, David Zurakowski
Affiliations
Free article

Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model

Frank Schuettauf et al. Vision Res. 2002 Sep.
Free article

Abstract

We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P<0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.

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