Characterization of immune response and mixed lymphocyte reactions in selected intra-H-2 recombinant strains
- PMID: 123542
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Characterization of immune response and mixed lymphocyte reactions in selected intra-H-2 recombinant strains
J Immunol.
1975 Feb.
Abstract
The genes controlling the immune response to the random linear terpolymers GAT and GLpro have been mapped in the Ir-1A or Ir-1B subregions with five lines of H-2-s/H-2-a recombinant mice. The I region also contains a third subregion, I-C, which codes for a lymphocyte-activating determinant, Lad2, controlling mixed lymphocyte reactivity. The mixed lymphocyte responses associated with I-C region disparity are compared with the stimulation noted with other H-2 region differences. Unidirectional lymphocyte activitation was associated with the Lad2 determinants in selected combinations.
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