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Comparative Study
. 2002 Oct;50(4):541-5.
doi: 10.1093/jac/dkf178.

Pharmacokinetics and ocular penetration of grepafloxacin in albino and pigmented rabbits

S Perez  1 , C Solans, M A Bregante, I Pinilla, M A García, F Honrubia
Affiliations
Comparative Study

Pharmacokinetics and ocular penetration of grepafloxacin in albino and pigmented rabbits

S Perez et al. J Antimicrob Chemother. 2002 Oct.

Abstract

The pharmacokinetics of grepafloxacin were determined in albino and pigmented rabbits following a single 10 mg/kg intravenous administration. The penetration of grepafloxacin into various ocular tissues was also determined after continuous intravenous infusion in both types of animal. Grepafloxacin showed a bicompartmental model of distribution in both pigmented and albino rabbits with significant differences in the pharmacokinetics between the two types of animal. After continuous intravenous infusion, significantly greater penetration of grepafloxacin was found in the iris, cornea and chorioretina of pigmented rabbits compared with albino rabbits.

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