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Review
. 2002 Oct;120(4):465-73.
doi: 10.1085/jgp.20028660.

Voltage sensor movements

Francisco Bezanilla  1
Affiliations
Review

Voltage sensor movements

Francisco Bezanilla. J Gen Physiol. 2002 Oct.
No abstract available

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Figures

F<sc>igure</sc> 1.
Figure 1.
Schematic representation of one particular arrangement of the labels of three consecutive residues in an α helical wheel. The rotation has been set to 180°. For details see the text.
F<sc>igure</sc> 2.
Figure 2.
Intracellular view of the minimized structure in the closed state. The sequence of segments in the left upper quadrant is gray, S1; blue, S2; orange, S3; green, S4; red, S5 pore loop and S6. The emphasized side chains shown in the upper quadrant correspond to the basic residues showing that they are all in the intracellular-facing side of the S4 segment.
F<sc>igure</sc> 3.
Figure 3.
Stereo extracellular view of the voltage-sensing region of one quadrant of the minimized model. The molecule has been tilted to position the S4 segment perpendicular to the plane of the figure (∼22°). Notice that in the closed state (A) the basic residues point toward the bottom left corner of the figure that corresponds to the intracellular side, while in the open state (B) they rotate ∼180°. Some residues are labeled for orientation. Residue E293 is in the S2 segment and D316 is in the S3 segment. Due to the tilt of the S1 and S2 segments they appear to be aligned.
See this image and copyright information in PMC

References

    1. Aggarwal, S.K., and R. MacKinnon. 1996. Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron. 16:1169–1177. - PubMed
    1. Asamoah, O.K., F. Bezanilla, and L.M. Loew. 2002. Probing the electric field in the Shaker potassium channel. Biophys. J. 82:233a. - PubMed
    1. Baker, O.S., H.P. Larsson, L.M. Mannuzzu, and E.Y. Isacoff. 1998. Three transmembrane conformation and sequence-dependent displacement of the S4 domain in Shaker K+ channel gating. Neuron. 20:1283–1294. - PubMed
    1. Bezanilla, F. 2000. The voltage sensor in voltage-dependent ion channels. Physiol. Rev. 80:555–592. - PubMed
    1. Blaustein, R.O., P.A. Cole, C. Williams, and C. Miller. 2000. Tethered blockers as molecular ‘tape measures’ for a voltage-gated K+ channel. Nat. Struct. Biol. 7:309–311. - PubMed

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