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Case Reports
. 2002 Sep 14;146(37):1743-5.

[Ototoxicity induced by clarithromycin]

[Article in Dutch]
W Kolkman  1 , J H M Groeneveld, H J C M Baur, H P Verschuur
Affiliations
  • PMID: 12357877
Case Reports

[Ototoxicity induced by clarithromycin]

[Article in Dutch]
W Kolkman et al. Ned Tijdschr Geneeskd. .

Abstract

A 76-year-old man developed a progressive bilateral hearing loss 4 days after starting a high dose of clarithromycin for atypical pulmonary tuberculosis. When the clarithromycin was discontinued the hearing improved subjectively but it worsened again upon reexposure. Halving the dose resulted in both an objective and subjective improvement in hearing, yet the original level of hearing was only obtained once clarithromycin had been permanently withdrawn. It would seem that this adverse effect is dose dependent. This seems to be the first published case study that demonstrates ototoxicity as a result of clarithromycin use.

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