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. 2002 Oct 9;124(40):11852-3.
doi: 10.1021/ja0277226.

Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors

Natalie A Dales  1 , Alexandra E Gould, James A Brown, Emily F Calderwood, Bing Guan, Charles A Minor, James M Gavin, Paul Hales, Virendar K Kaushik, Michael Stewart, Peter J Tummino, Chad S Vickers, Timothy D Ocain, Michael A Patane
Affiliations

Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors

Natalie A Dales et al. J Am Chem Soc. .

Abstract

Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and selective ACE2 inhibitors. To this end, picomolar inhibitors of ACE2 were designed and synthesized.

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