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Comparative Study
. 2002 Oct;110(4):781-6.
doi: 10.1542/peds.110.4.781.

Cost-benefit analysis of universal tandem mass spectrometry for newborn screening

Edgar J Schoen  1 , John C Baker, Christopher J Colby, Trinh T To
Affiliations
Comparative Study

Cost-benefit analysis of universal tandem mass spectrometry for newborn screening

Edgar J Schoen et al. Pediatrics. 2002 Oct.

Abstract

Objective: To estimate potential costs and benefits of routinely using tandem mass spectrometry (MS/MS) to screen newborns for inborn errors of metabolism.

Method: Analysis of costs and benefits resulting from use of MS/MS in screening of 32 000 newborn infants using data from the Kaiser Permanente Medical Care Program of Northern California plus other published data.

Setting: A large health maintenance organization.

Results: In the base scenario, the cost per quality-adjusted life year saved by MS/MS screening was $5827; in the least favorable scenario, this cost was $11 419, and in the most favorable scenario, $736.

Conclusion: Costs per quality-adjusted life year saved by MS/MS screening for inborn errors of metabolism compare favorably with other mass screening programs, including those for breast and prostate cancer.

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