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Review
. 2002 Oct;1(10):821-5.
doi: 10.1038/nrd919.

Two decades of orphan product development

Marlene E Haffner  1 , Janet Whitley, Marie Moses
Affiliations
Review

Two decades of orphan product development

Marlene E Haffner et al. Nat Rev Drug Discov. 2002 Oct.

Abstract

Over the past 20 years, incentives of the Orphan Drug Act (ODA), the largest single source of extramural clinical grants at the US Food and Drug Administration, have had a substantial impact on public health. ODA incentives have contributed to the development of many innovative biotechnology products, and as our understanding of the human genome evolves, it is anticipated that pharmacogenomics will result in the identification of more 'orphan diseases'.

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