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. 2002 Nov 5;779(2):307-12.
doi: 10.1016/s1570-0232(02)00399-9.

High-performance liquid chromatographic method for the determination of gabapentin in human plasma

Z Zhu  1 , L Neirinck
Affiliations

High-performance liquid chromatographic method for the determination of gabapentin in human plasma

Z Zhu et al. J Chromatogr B Analyt Technol Biomed Life Sci. .

Abstract

A sensitive high-performance liquid chromatography (HPLC) method using UV detection for the determination of gabapentin in human plasma has been developed. In this method, gabapentin was extracted from human plasma with a reversed-phase solid-phase extraction (SPE) cartridge followed by derivatization with phenylisothiocyanate. Analysis was achieved by using a HPLC system that was equipped with a UV detector. The quantitation limit of gabapentin in human plasma was 0.03 microg/ml. The method is sensitive with excellent selectivity and reproducibility and it has been applied to a bioequivalence clinical study with great success.

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