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Review
. 2002 Sep;4(11):1193-202.
doi: 10.1016/s1286-4579(02)01645-3.

Thalidomide in the treatment of leprosy

Steve K Teo  1 , Ken E Resztak, Michael A Scheffler, Karin A Kook, Jerry B Zeldis, David I Stirling, Steve D Thomas
Affiliations
Free article
Review

Thalidomide in the treatment of leprosy

Steve K Teo et al. Microbes Infect. 2002 Sep.
Free article

Abstract

Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflammatory cytokine TNF-alpha produced by monocytes.

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