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Review
. 2002 Oct;12(5):516-22.
doi: 10.1016/s0959-4388(02)00354-9.

PTEN function in mammalian cell size regulation

Stéphanie Backman  1 , Vuk Stambolic, Tak Mak
Affiliations
Review

PTEN function in mammalian cell size regulation

Stéphanie Backman et al. Curr Opin Neurobiol. 2002 Oct.

Abstract

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.

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