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. 2002 Oct 3;419(6906):531-4.
doi: 10.1038/nature01094.

Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14

Malcolm J Gardner  1 , Shamira J Shallom, Jane M Carlton, Steven L Salzberg, Vishvanath Nene, Azadeh Shoaibi, Anne Ciecko, Jeffery Lynn, Michael Rizzo, Bruce Weaver, Behnam Jarrahi, Michael Brenner, Babak Parvizi, Luke Tallon, Azita Moazzez, David Granger, Claire Fujii, Cheryl Hansen, James Pederson, Tamara Feldblyum, Jeremy Peterson, Bernard Suh, Sam Angiuoli, Mihaela Pertea, Jonathan Allen, Jeremy Selengut, Owen White, Leda M Cummings, Hamilton O Smith, Mark D Adams, J Craig Venter, Daniel J Carucci, Stephen L Hoffman, Claire M Fraser
Affiliations

Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14

Malcolm J Gardner et al. Nature. .

Abstract

The mosquito-borne malaria parasite Plasmodium falciparum kills an estimated 0.7-2.7 million people every year, primarily children in sub-Saharan Africa. Without effective interventions, a variety of factors-including the spread of parasites resistant to antimalarial drugs and the increasing insecticide resistance of mosquitoes-may cause the number of malaria cases to double over the next two decades. To stimulate basic research and facilitate the development of new drugs and vaccines, the genome of Plasmodium falciparum clone 3D7 has been sequenced using a chromosome-by-chromosome shotgun strategy. We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome.

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Comment in

  • Integrated programme is key to malaria control.
    Utzinger J, Tanner M, Kammen DM, Killeen GF, Singer BH. Utzinger J, et al. Nature. 2002 Oct 3;419(6906):431. doi: 10.1038/419431a. Nature. 2002. PMID: 12368831 No abstract available.
  • The grand assault.
    Doolittle RF. Doolittle RF. Nature. 2002 Oct 3;419(6906):493-4. doi: 10.1038/419493a. Nature. 2002. PMID: 12368861 No abstract available.
  • Biological revelations.
    Wirth DF. Wirth DF. Nature. 2002 Oct 3;419(6906):495-6. doi: 10.1038/419495a. Nature. 2002. PMID: 12368862 No abstract available.

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