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. 2002;31(4):205-10.
doi: 10.1080/030097402320318387.

Cytokine profile in Behçet's disease patients. Relationship with disease activity

Kamel Hamzaoui  1 , Agnes Hamzaoui, Fethi Guemira, Moncef Bessioud, M'hamed Hamza, Khaled Ayed
Affiliations

Cytokine profile in Behçet's disease patients. Relationship with disease activity

Kamel Hamzaoui et al. Scand J Rheumatol. 2002.

Abstract

Objective: To analyse proinflammatory Th1 and Th2 cytokines in patients with Behçet's disease (BD) in relation to disease activity.

Methods: Forty-five BD patients (25 in active stage) were investigated with ELISA for estimation of cytokines levels. Furthermore, cytokines intracellular synthesis (IL-4 and IFN-gamma) of CD4+ T cells was studied.

Results: Active and in remission BD patients showed increased serum levels of Th1 (IFN-gamma, IL-12) and Th2 (IL-4, IL-6 and IL-10) cytokines. Active BD was characterized by a higher increase of IL-6, IL-10 and a striking increase of IL-17, IL-18 and IFN-gamma, compared to remission RD. Upon in vitro stimulation, the percentages of CD4+ T cells containing IFN-gamma and CD40L were higher in active BD compared to healthy controls.

Conclusion: Our results suggest that the microenvironment of CD4+ T cells in active BD may induce the production of more cells committed to Th1 than in BD patients in remission and healthy controls.

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