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Comment
. 2002 Oct 15;99(21):13374-6.
doi: 10.1073/pnas.212514799. Epub 2002 Oct 7.

Error catastrophe and antiviral strategy

Manfred Eigen  1
Affiliations
Comment

Error catastrophe and antiviral strategy

Manfred Eigen. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig 1.
Fig 1.
Relative population numbers of binary sequences Sk (ordinate) as functions of single-digit error rate (1 − q) (abscissa). The length of all binary sequences is N = 20. All 2N ≈ 106 sequences are degenerate in their reproductivity except for one “master” sequence Sm, which reproduces 10 times more efficiently than the rest. The resulting quasispecies distribution is centered at the master sequence (“0” errors). The numbers 1, 2, … 20 refer to the sum of all 1-, 2-, … 20-error mutants. The red curve refers to the consensus sequence, which shows a sharp first-order phase transition at the error threshold.
Fig 2.
Fig 2.
Kinetic profile for the infection of E. coli by phage Qβ. The total infection cycle lasts about 40 min. The ordinate refers to the rates (i.e., the number of particles formed per minute and per host cell) that are plotted as functions of time. Red lines represent proteins (coat protein and replicase); blue lines, RNA (plus and minus strands); and the green line, complete virus particles.
See this image and copyright information in PMC

Comment on

References

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