Review
doi: 10.1016/s0092-8674(02)01010-3.
Structures of SET domain proteins: protein lysine methyltransferases make their mark
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- PMID: 12372294
- DOI: 10.1016/s0092-8674(02)01010-3
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Review
Structures of SET domain proteins: protein lysine methyltransferases make their mark
Cell.
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Free article
Abstract
Proteins bearing the widely distributed SET domain have been shown to methylate lysine residues in histones and other proteins. In this issue, three-dimensional structures are reported for three very different SET domain-containing proteins. The structures reveal novel folds for several new domains, including SET, and provide early insights into mechanisms of catalysis and molecular recognition in this family of enzymes.
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