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Case Reports
. 2002;108(3):150-3.
doi: 10.1159/000064701.

A rare, in-frame BCR-ABL fusion (e13a3) in a patient with an aggressive chronic myeloid leukaemia

Ivone B Otazú  1 , María Belén Rivero, Renata Olício, Augusto Pinto, Ilana Zalcberg, Héctor N Seuánez
Affiliations
Case Reports

A rare, in-frame BCR-ABL fusion (e13a3) in a patient with an aggressive chronic myeloid leukaemia

Ivone B Otazú et al. Acta Haematol. 2002.

Abstract

We have identified a rare BCR-ABL chimaeric gene with multiplex and nested RT-PCR in a patient with an unusually aggressive chronic myeloid leukaemia. cDNA sequencing showed an in-frame rearrangement with a breakpoint in BCR exon e13 (b2) and fusion with ABL exon 3 following skipping of the entire ABL exon a2. These data confirm the heterogeneity of breakpoints in BCR-ABL rearrangements.

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