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. 2002;23(1-3):161-2.
doi: 10.1007/s00726-001-0122-6.

Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration

D A Baker  1 , H Shen, P W Kalivas
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Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration

D A Baker et al. Amino Acids. 2002.

Abstract

Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.

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