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Review
. 2002 Oct 15;99(21):13371-3.
doi: 10.1073/pnas.222543099. Epub 2002 Oct 8.

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

Timothy D Warner  1 , Jane A Mitchell
Affiliations
Review

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

Timothy D Warner et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
A COX continuum? Two distinct genes for COX-1 and -2 may give rise to a number of constitutive and inducible COX proteins with overlapping functions. Considering prostanoid production by a COX continuum may help us appreciate which enzymes underlie prostanoid production in different tissues as well as the actions of traditional NSAIDs, newer COX-2-selective drugs, and acetaminophen (“COX-2b,” as suggested in ref. ; COX-3, as suggested in ref. 2).
See this image and copyright information in PMC

Comment on

References

    1. Vane J R. J Physiol Pharmacol. 2000;51:573–586. - PubMed
    1. Chandrasekharan N V, Dai H, Roos L T, Evanson N K, Tomsik J, Elton T S, Simmons D L. Proc Natl Acad Sci USA. 2002;99:13926–13931. - PMC - PubMed
    1. Vane J R. Nat New Biol. 1971;231:232–235. - PubMed
    1. Samuelsson B. Biosci Rep. 1983;3:791–813. - PubMed
    1. Mitchell J A, Warner T D. Br J Pharmacol. 1999;128:1121–1132. - PMC - PubMed

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