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. 2002 Oct 10;419(6907):583-6.
doi: 10.1038/nature01079.

Somatic cell nuclear transfer

I Wilmut  1 , N Beaujean, P A de Sousa, A Dinnyes, T J King, L A Paterson, D N Wells, L E Young
Affiliations

Somatic cell nuclear transfer

I Wilmut et al. Nature. .

Abstract

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

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