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Review
. 2002 Oct;35(10):817-25.
doi: 10.1021/ar000138m.

Characterization of nucleic acids by nanopore analysis

David W Deamer  1 , Daniel Branton
Affiliations
Review

Characterization of nucleic acids by nanopore analysis

David W Deamer et al. Acc Chem Res. 2002 Oct.

Abstract

Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.

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