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Review
. 2002 Nov;61 Suppl 2(Suppl 2):ii25-8.
doi: 10.1136/ard.61.suppl_2.ii25.

Balancing the immune system: Th1 and Th2

W Van Eden  1 , R Van Der Zee, P Van Kooten, S E Berlo, P M Cobelens, A Kavelaars, C J Heijnen, B Prakken, S Roord, S Albani
Affiliations
Review

Balancing the immune system: Th1 and Th2

W Van Eden et al. Ann Rheum Dis. 2002 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Three mechanisms of anti-inflammatory T cell induction by hsp. APL regulation: microbial hsp reactive T cells perceive self hsp homologues as partial agonists or APLs and develop a regulatory phenotype. Mucosal tolerance: hsp reactive T cells recognise microbial hsp in the tolerising GALT and display a tolerising activity when confronted with self hsp expressed elsewhere in the body. Anergy: non-professional or non-activated antigen presenting cells present constitutively self hsp in the absence of costimulation. The resulting self hsp specific "anergic" T cell can exert regulatory activity after the encounter with professional or activated APC presenting upregulated self hsp. Self hsp in lighter grey tone. Microbial hsp in darker grey tone.
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