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Review
. 2002 Nov;61 Suppl 2(Suppl 2):ii82-3.
doi: 10.1136/ard.61.suppl_2.ii82.

Tumour necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis

J Lam  1 , Y Abu-Amer, C A Nelson, D H Fremont, F P Ross, S L Teitelbaum
Affiliations
Review

Tumour necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis

J Lam et al. Ann Rheum Dis. 2002 Nov.
No abstract available

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Figures

Figure 1
Figure 1
TNFα mediated osteoclastogenesis requires RANKL. TNFα targets two cells in the osteoclastogenic process. In the first instance the cytokine induces RANKL expression by stromal cells. Increased RANKL interacting with its receptor RANK, in a cell contact dependent manner, stimulates osteoclast differentiation. TNFα also directly provokes osteoclast precursors to differentiate, but this event requires permissive levels of RANKL.
See this image and copyright information in PMC

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