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Clinical Trial
. 2002 Nov;70(11):6471-4.
doi: 10.1128/IAI.70.11.6471-6474.2002.

Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans

Geert J Wanten  1 , Mihai G Netea, Ton H Naber, Jo H Curfs, Liesbeth E Jacobs, Trees J Verver-Jansen, Bart-Jan Kullberg
Affiliations
Clinical Trial

Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans

Geert J Wanten et al. Infect Immun. 2002 Nov.

Abstract

Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.

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Figures

FIG. 1.
FIG. 1.
Effects of lipid emulsions or the placebo after 8- and 24-h incubations on the growth of samples of C. albicans in cell-free serum. Results are ratios of growth obtained after lipid infusion to growth obtained before lipid infusion. ∗, significance (P ≤ 0.01) of treatment effects relative to results with the placebo and LCT; ∗∗, significance (P ≤ 0.02) of treatment effects relative to results with the placebo and LCT.
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