Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2002 Nov;70(11):6471-4.
doi: 10.1128/IAI.70.11.6471-6474.2002.

Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans

Geert J Wanten  1 , Mihai G Netea, Ton H Naber, Jo H Curfs, Liesbeth E Jacobs, Trees J Verver-Jansen, Bart-Jan Kullberg
Affiliations
Clinical Trial

Parenteral administration of medium- but not long-chain lipid emulsions may increase the risk for infections by Candida albicans

Geert J Wanten et al. Infect Immun. 2002 Nov.

Abstract

Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Effects of lipid emulsions or the placebo after 8- and 24-h incubations on the growth of samples of C. albicans in cell-free serum. Results are ratios of growth obtained after lipid infusion to growth obtained before lipid infusion. ∗, significance (P ≤ 0.01) of treatment effects relative to results with the placebo and LCT; ∗∗, significance (P ≤ 0.02) of treatment effects relative to results with the placebo and LCT.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Arias Diaz, J., J. M. Rodriguez, E. Vara, C. Garcia, J. Torres Melero, and C. Garcia Carreras. 1996. NO2/NO3 and cytokine plasma profiles under different postoperative parenteral nutrition regimens. Nutrition 12:89-92. - PubMed
    1. Baggiolini, M., P. Loetscher, and B. Moser. 1995. Interleukin-8 and the chemokine family. Int. J. Immunopharmacol. 17:103-108. - PubMed
    1. Bellinati Pires, R., D. L. Waitzberg, M. M. Salgado, and M. M. Carneiro Sampaio. 1993. Functional alterations of human neutrophils by medium-chain triglyceride emulsions: evaluation of phagocytosis, bacterial killing, and oxidative activity. J. Leukoc. Biol. 53:404-410. - PubMed
    1. Braxton, C. C., S. M. Coyle, W. J. Montegut, T. van-der-Poll, M. Roth, and S. E. Calvano. 1995. Parenteral nutrition alters monocyte TNF receptor activity. J. Surg. Res. 59: 23-28. - PubMed
    1. D'Angio, R., R. A., Quercia, N. K. Treiber, J. C. Mclaughlin, and J. Klimek. 1987. The growth of microorganisms in total parenteral admixtures. J. Parenter. Enteral Nutr. 11:394-397. - PubMed

Publication types

MeSH terms