Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohn
- PMID: 12381347
- DOI: 10.1016/s0008-8749(02)00504-x
Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohn
Abstract
Langman and Cohn have written a paper entitled "If the immune repertoire evolved to be large, random, and somatically generated, then em leader " This paper uses reductionist logic to prove that the minimal model of immunity proposed by Langman and Cohn is the only reasonable description of the workings of the immune system. Here we analyze the logic behind this model and show that the complexity of the real immune system contradicts the teachings of Langman and Cohn.
Comment in
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If the immune repertoire evolved to be large, random, and somatically generated, then..Cell Immunol. 2002 Mar-Apr;216(1-2):15-22. doi: 10.1016/s0008-8749(02)00503-8. Cell Immunol. 2002. PMID: 12381346 Review.
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Does complexity belie a simple decision--on the Efroni and Cohen critique of the minimal model for a self-nonself discrimination.Cell Immunol. 2003 Feb;221(2):138-42. doi: 10.1016/s0008-8749(03)00075-3. Cell Immunol. 2003. PMID: 12747955
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