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Review
. 2002 Oct;8(10):464-8.
doi: 10.1016/s1471-4914(02)02405-x.

Pathogenic significance of IgA receptor interactions in IgA nephropathy

Renato C Monteiro  1 , Ivan C Moura, Pierre Launay, Toshinao Tsuge, Elie Haddad, Marc Benhamou, Max D Cooper, Michelle Arcos-Fajardo
Affiliations
Review

Pathogenic significance of IgA receptor interactions in IgA nephropathy

Renato C Monteiro et al. Trends Mol Med. 2002 Oct.

Abstract

IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, frequently progresses to renal failure. The pathogenesis of this disease involves the deposition of undergalactosylated IgA1 complexes in the glomerular mesangium. How the IgA1 complexes are generated and why they are deposited in the mesangium remains unclear. We propose a model wherein two types of IgA receptors participate in sequential steps to promote the development of IgAN, with FcalphaRI (CD89) being initially involved in the formation of circulating IgA-containing complexes and, subsequently, transferrin receptor (CD71) in mediating mesangial deposition of IgA1 complexes.

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