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. 2002 Nov;46(11):3627-9.
doi: 10.1128/AAC.46.11.3627-3629.2002.

TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511

Rodrigo Alonso  1 , Guy Gerbaud, Marc Galimand, Patrice Courvalin
Affiliations

TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511

Rodrigo Alonso et al. Antimicrob Agents Chemother. 2002 Nov.

Abstract

Clinical isolate Escherichia coli BM4511 was resistant to broad-spectrum penicillins in the presence or in the absence of beta-lactamase inhibitors but remained susceptible to cephalosporins. Resistance was due to production of a new TEM-type beta-lactamase, designated TEM-103/IRT-28, characterized by the Arg(275)Leu substitution and encoded by the ca. 62-kb pIP845 conjugative plasmid of the IncI1 incompatibility group.

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