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. 1975 Mar;79(3):419-34.
doi: 10.1093/genetics/79.3.419.

Genetic control of phosphate-metabolizing enzymes in Neurospora crassa: relationships among regulatory mutations

B S Littlewood, W Chia, R L Metzenberg

Genetic control of phosphate-metabolizing enzymes in Neurospora crassa: relationships among regulatory mutations

B S Littlewood et al. Genetics. 1975 Mar.

Abstract

In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1, pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pcon-c (constitutive) mutations reside in the same cistron. preg-c (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others.

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References

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