Antigen presentation by dendritic cells in vivo

Affiliations

Comment

Evelyne Mougneau et al. J Exp Med. 2002.

. 2002 Oct 21;196(8):1013-6.

doi: 10.1084/jem.20021636.

¹ Centre National de la Recherche Scientifique UMR6097, University of Nice-Sophia Antipolis, 06560 Valbonne, France.

No abstract available

Comment on

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.
Scheinecker C, McHugh R, Shevach EM, Germain RN. Scheinecker C, et al. J Exp Med. 2002 Oct 21;196(8):1079-90. doi: 10.1084/jem.20020991. J Exp Med. 2002. PMID: 12391019 Free PMC article.
Immune tolerance after delivery of dying cells to dendritic cells in situ.
Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K, Steinman RM. Liu K, et al. J Exp Med. 2002 Oct 21;196(8):1091-7. doi: 10.1084/jem.20021215. J Exp Med. 2002. PMID: 12391020 Free PMC article.
The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.
Belz GT, Behrens GM, Smith CM, Miller JF, Jones C, Lejon K, Fathman CG, Mueller SN, Shortman K, Carbone FR, Heath WR. Belz GT, et al. J Exp Med. 2002 Oct 21;196(8):1099-104. doi: 10.1084/jem.20020861. J Exp Med. 2002. PMID: 12391021 Free PMC article.

1. Hawiger, D., K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J.V. Ravetch, R.M. Steinman, and M.C. Nussenzweig. 2001. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194:769–780. - PMC - PubMed
1. Steinman, R.M., and M.C. Nussenzweig. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA. 99:351–358. - PMC - PubMed
1. Matzinger, P., and S. Guerder. 1989. Does T cell tolerance require a dedicated antigen-presenting cell? Nature. 338:74–76. - PubMed
1. Kurts, C., W.R. Heath, F.R. Carbone, J. Allison, J.F. Miller, and H. Kosaka. 1996. Constitutive class I-restricted exogenous presentation of self-antigens in vivo. J. Exp. Med. 184:923–930. - PMC - PubMed
1. Kurts, C., H. Kosaka, F.R. Carbone, J.F.A.P. Miller, and W.R. Heath. 1997. Class I–restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med. 186:239–245. - PMC - PubMed