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Review
. 2002 Oct 29;99(22):13969-71.
doi: 10.1073/pnas.232574399. Epub 2002 Oct 21.

New careers for antioxidants

Douglas E Brash  1 , P A Havre
Affiliations
Review

New careers for antioxidants

Douglas E Brash et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig 1.
Fig 1.
Chemopreventive antioxidants are usually considered in terms of radical scavenging, but Seo et al. (7) present evidence that selenium up-regulates DNA excision repair via P53. These preventive roles are complemented by other recent studies, indicating a corrective activity of antioxidants: inducing apoptosis selectively in transformed cells.
Fig 2.
Fig 2.
Selenomethionine activates P53 via the selenoprotein thioredoxin, which activates Ref-1's ability to alter the redox state of P53 cysteines. P53 activated by SeMet elevates DNA excision repair, but does not induce apoptosis or cell cycle arrest as it does when DNA damage activates P53 by phosphorylation.
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Comment on

References

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