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Review
. 2002 Nov 1;70(3):357-60.
doi: 10.1002/jnr.10389.

Role of mitochondrial dysfunction in Alzheimer's disease

Rudy Castellani  1 , Keisuke Hirai, Gjumrakch Aliev, Kelly L Drew, Akihiko Nunomura, Atsushi Takeda, Adam D Cash, Mark E Obrenovich, George Perry, Mark A Smith
Affiliations
Review

Role of mitochondrial dysfunction in Alzheimer's disease

Rudy Castellani et al. J Neurosci Res. .

Abstract

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.

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