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Review
. 2002 Apr;13(2):169-82, v.
doi: 10.1016/s1042-3680(01)00005-5.

Critical mechanisms of secondary damage after inflicted head injury in infants and children

Randall A Ruppel  1 , Robert S B Clark, Hülya Bayir, Margaret A Satchell, Patrick M Kochanek
Affiliations
Review

Critical mechanisms of secondary damage after inflicted head injury in infants and children

Randall A Ruppel et al. Neurosurg Clin N Am. 2002 Apr.

Abstract

A number of critical mechanisms are involved in the pathophysiology of inflicted head injury. Excitotoxicity, oxidative stress, inflammation, programmed cell death, and mediators of blood flow and metabolism all contribute to secondary injury after abusive head trauma. These mechanisms are reviewed and the implications for clinical practice discussed.

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