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. 1975 Oct;13(9-10):533-50.
doi: 10.1007/BF00484913.

On the defect of synthesis ceruloplasmin in the liver polyribosomes in Wilson's disease

V S Gaitskhoki, O I Kisselev, K A Moshkov, L V Puchkova, M M Shavlovski, V S Shulman, V G Vacharlovski, S A Neifakh

On the defect of synthesis ceruloplasmin in the liver polyribosomes in Wilson's disease

V S Gaitskhoki et al. Biochem Genet. 1975 Oct.

Abstract

Comparative immunochemical analysis of ceruloplasmin-synthesizing polyribosomes in liver biopsies from control subjects and homozygous carriers of the Wilson's mutation was performed. According to I125-antibody binding data, the amount of ceruloplasmin-forming liver polysomes in patients with Wilson's disease was 10--20 times lower than that in non-Wilson patients. Correspondingly, the pulse labeling of ceruloplasmin polypeptides was decreased several-fold in the cell-free liver preparations from patients with Wilson's disease.

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