Genetic susceptibility to aminoglycoside ototoxicity: how many are at risk?
- PMID: 12394346
- DOI: 10.1097/00125817-200209000-00004
Genetic susceptibility to aminoglycoside ototoxicity: how many are at risk?
Abstract
Purpose: To assess the occurrence of two mutations associated with susceptibility to aminoglycoside ototoxicity.
Methods: Genetic analysis of anonymized, residual diagnostic specimens.
Results: One occurrence of the A1555G mutation and seven occurrences of the 961delT + C(n) nucleotide change were found. Two previously unreported sequence changes, T961G and 956-960insC, were also found in six and five specimens, respectively.
Conclusions: Genetic susceptibility to aminoglycoside ototoxicity may be more common than previously suspected. Further study of the 961delT + C(n) mutation is recommended to confirm its role in aminoglycoside ototoxicity and assess penetrance and variability with and without exposure to aminoglycoside antibiotics.
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