Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1975 Dec;29(3):297-304.
doi: 10.1099/0022-1317-29-3-297.

Interferon induction by viruses and polynucleotides: a differential effect of comptothecin

K T Atherton, D C Burke
Comparative Study

Interferon induction by viruses and polynucleotides: a differential effect of comptothecin

K T Atherton et al. J Gen Virol. 1975 Dec.

Abstract

The plant alkaloid comptothecin inhibits interferon production induced by Newcastle disease virus (NDV) or ultraviolet-irradiated NDV in chick and human cells, and by Sindbis virus in chick cells. It has no effect on interferon production induced by poly (rI).poly(rC) in chick and human cells. No effect of comptothecin could be detected on the multiplication of NDV, and it is concluded that the inhibition reflects a difference between interferon induction by viruses and by polynucleotides.

PubMed Disclaimer

Publication types

LinkOut - more resources