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. 1975 Nov 21;44(3):303-5.
doi: 10.1007/BF00428912.

Methaqualone: tolerance and physical dependence in mice

H P Alpern, C A Greer, J S Stripling, A C Collins, R K Olson

Methaqualone: tolerance and physical dependence in mice

H P Alpern et al. Psychopharmacologia. .

Abstract

Tolerance and physical dependence was produced in C57Bl/6 male mice that had been exposed, for 36 days, to methaqualone in food pellets via an automated system. Tolerance was revealed in the reduction of sleep-times following intraperitoneal injection of methaqualone. Physical dependence was manifested as an alteration in neural sensitivity to flurothyl-induced convulsions.

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References

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