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Clinical Trial
. 2002 Oct;21(10):978-9.
doi: 10.1097/00006454-200210000-00019.

Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers

Margaret Rennels  1 , James King Jr, Robert Ryall, Susan Manoff, Thomas Papa, Andrea Weddle, James Froeschle
Affiliations
Clinical Trial

Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers

Margaret Rennels et al. Pediatr Infect Dis J. 2002 Oct.

Abstract

Two injections of tetravalent (Groups A, C, Y and W-135) meningococcal polysaccharide vaccine conjugated to diphtheria were given to 30 toddlers at dosages of 1, 4 and 10 microg/ml polysaccharide of each serogroup. Reactogenicity was acceptable at all dosages. The 4-microg/ml dose appears to be immunologically optimal.

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